– Oxymatrine –

The inhibitory effect of
oxymatrine on
hepatitis C virus in vitro

by Chen Y, Li J, Zeng M, Lu L, Qu D, Mao Y, Fan Z & Hua J.

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Shanghai Institute of Digestive Diseases, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China.

OBJECTIVE:

To study the inhibitory effect of oxymatrine on HCV in vitro. METHODS: SMMC-7721 cells transfected with pBK-HCV using lipofectin transfection protocal were treated with oxymatrine. bDNA signal amplification assay and MTT colorimetric assay were used for intracellular HCV RNA and cytotoxicity.

results:

The stable HCV expression cell model established here could be used as a tool for medicine screen. Oxymatrine at the concentration of 100~1000 mug/ml could significantly decrease the level of intracellular HCV RNA. No cytotoxicity was shown in such concentrations.

conclusion:

Oxymatrine has an anti-HCV potential activity in vitro.

For more information on Oxymatrine, please click below.
Oxymatrine Article 1, Oxymatrine Article 2